Sentence examples for binding pocket as it from inspiring English sources

Although models generated with E134 as the conserved glutamic acid scored equally well when compared against the consensus structure, they would likely be deemed implausible by visual inspection as helix C was distorted upwards away from the active site instead of lining the back of the ATP binding pocket as it does in other kinases.

The lack of the Thr201: ZOL hydrogen bond in the T201A FPPS structure (4KFA) does not greatly alter the position of the imidazole ring in the allylic binding pocket, as it is still properly oriented by the Lys200 ZOL hydrogen bond (Fig. 3B).

Accordingly, the orientation of the retinal in its binding pocket, as known from the dark state rhodopsin structure[1], determines its longitudinal orientation during uptake and release.

Supporting NMR titration data further indicated that this peptide binds with the phosphothreonine in the canonical binding pocket as might be predicted.

Forced twisting of the polyene backbone away from its normally planar configuration induced by the binding pocket as well as the electrostatic environment surrounding the chromophore are major factors that influence its absorbance maximum.

Taking into account that subtle differences in the ATP binding pocket (as well as overall differences of the structural context) could have a big impact on the inhibitor binding, it could be expected that outcomes of such substitutions in FGFR2 could be different as supported by recent observations for FGFR2 V564I (Byron et al., 2013).

Moreover, several residues known to be critical in the caspase-3 catalytic centre and binding pocket, as well as the active-site pentapeptide motif Q172ACRG176 were present in the deduced Lyccasp3.

The co-crystal structure of PAP and TBBPA bound to SULT1E1 reveals TBBPA binding in the same substrate binding pocket as E2.

These functional sites include the residues involved in coordinating Na+ and GABA in the transporter binding pocket, as well as those that serve as extracellular and cytoplasmic gates.

Now, we present direct experimental evidence, as correctly prompted by the reviewers, on the indispensible role of adenosine binding pocket as well.

However, it enables in some instances the simultaneous binding of two or even three molecules, which interact with the binding pocket as well as with each other, resulting in a more stable binding conformation [199].