Sentence examples for binding pocket as an from inspiring English sources

For instance, though the capsaicin-bound open state of TRPV1 was determined, the capsaicin molecule was registered within the binding pocket as an electron density much smaller than its chemical structure (Fig. 1D) (Cao et al., 2013), hence it remained unclear how capsaicin is orientated.

Specifically, we analyzed the role of the putative proton-coupling motif 41ExxER45; the role of charged residues in the extended loop R264R266K267; and residues in the substrate binding pocket as well as a predicted a salt bridge L49, K164, Q358, Y388, and E476 (Newstead, 2011; Newstead et al., 2011; Solcan et al., 2012; Doki et al., 2013).

Supporting NMR titration data further indicated that this peptide binds with the phosphothreonine in the canonical binding pocket as might be predicted.

However, it enables in some instances the simultaneous binding of two or even three molecules, which interact with the binding pocket as well as with each other, resulting in a more stable binding conformation [199].

Taking into account that subtle differences in the ATP binding pocket (as well as overall differences of the structural context) could have a big impact on the inhibitor binding, it could be expected that outcomes of such substitutions in FGFR2 could be different as supported by recent observations for FGFR2 V564I (Byron et al., 2013).

Moreover, several residues known to be critical in the caspase-3 catalytic centre and binding pocket, as well as the active-site pentapeptide motif Q172ACRG176 were present in the deduced Lyccasp3.

Accordingly, the orientation of the retinal in its binding pocket, as known from the dark state rhodopsin structure[1], determines its longitudinal orientation during uptake and release.

The co-crystal structure of PAP and TBBPA bound to SULT1E1 reveals TBBPA binding in the same substrate binding pocket as E2.

These functional sites include the residues involved in coordinating Na+ and GABA in the transporter binding pocket, as well as those that serve as extracellular and cytoplasmic gates.

Now, we present direct experimental evidence, as correctly prompted by the reviewers, on the indispensible role of adenosine binding pocket as well.

The differential sensitivity of these proteins is most likely due to different amino acid side chains being present in the binding pocket, as well as different large scale motions that may affect binding to this site.