Sentence examples for binding pocket and therefore from inspiring English sources

These differences lead to structural changes in enzyme substrate binding pocket and therefore add to differences in the potency of inhibitors in the different enzymes.

However, compared to the first pose, the aromatic moiety of the ligand is not located in the aromatic cavity of the binding pocket and therefore not involved in π π interactions.

Given the diversity of Mups in rodents, it was originally thought that different Mups may have differently shaped binding pockets and therefore bind different pheromones.

The phenyl rings attached to the indazole of these two compounds occupy different binding pockets and therefore make different interactions with the protein.

This will result in high spatial proximity for the two methylated lysine binding pockets, and therefore the H3K36me3 markers on each side of the nucleosome would be easy to recognize and MRG molecules will spread on the chromatin surface (Fig. 5F).

Most protein kinase inhibitors target the ATP-binding pocket and therefore tend to be poorly selective (Davis, 2000; Bain et al., 2007).

These findings suggest that certain substitutions may promote an involuntary cation-binding site within a putatively metal-free peptide-binding pocket and therefore change the innate specificity of antigen recognition.

The newly solved structure of EBOV GP bound to NPC1 confirms our findings, revealing that this residue dips into the GP receptor-binding pocket and is therefore critical to the binding interface.

The simulations therefore unveil interactions of GABA within the binding pocket, and explain experimental data, which indicate that Arg is critical for the efficient functioning of the receptor.

Therefore, the mutation I211A adjusted the local structure near the binding pocket and stabilizes the substrate binding with the specificity subsite of OPHs.

lid, binding pocket and oxyanion hole are hotspots for mutagenesis.