Sentence examples for binding pocket and hence from inspiring English sources
This indicates that (as expected) denaturing sample preparation and SDS-PAGE disintegrates the hapten binding pocket and hence separates antibody and payload.
72, 74 The extruded ligand prevents alignment of helix 12 over the ligand-binding pocket and hence formation of a complete coactivator recruitment surface.
In the present study, we use a synthetic ATPγS analogue that displays steric complementarity to the ATP-binding pocket and hence allows identification of protein substrates based on selective thiophosphorylation.
The unbound experimental protein structures often lack appropriate binding pockets and thus standard virtual screening techniques will fail.
Our computer-assisted modeling sheds new light on why we observed a dramatic reduction in PGRN endocytosis when ligands, such as NTS and human PGRN588 593, were present in vitro: the binding pocket and protein protein interactions of NTS and PGRN's C-terminal binding motif significantly overlap, hence explaining the competitive inhibition effect.
Upon ligand binding, solvent molecules around the binding pocket and the ligand become displaced or rearranged.
lid, binding pocket and oxyanion hole are hotspots for mutagenesis.
The docking site was prepared as an area encompassing both the ligand binding pocket and the peptide cofactor binding site.
The modelled DXR has a three-domain architecture and its active site comprised of a cofactor (NADPH) binding pocket and the substrate-binding pocket.
QM/MM calculation for the reaction without Mg2+ ions in the binding pocket.
