Sentence examples for binding pocket and a from inspiring English sources

Traditional nuclear medicine ligands were designed to target cellular receptors or transporters with a binding pocket and a defined structure activity relationship.

We employed a hybrid approach to study the dynamic structure of Deinococcus radiodurans (Dra) YCC: crystal structures of isolated domains reveal a hexameric CT core with extended substrate binding pocket and a dimeric BC domain.

However, water-mediated hydrogen bonds and a unique cation-π sandwich stacking allow 447-52D to be broadly reactive with V3 containing both the GPGR and GPGQ crown motifs, while the deeper binding pocket and a buried Glu in the binding site of 537-10D litst its reactivity to only V3 containing the GPGR motif.

The c-Cbl TKB domain consists of three tightly-connected domains: a divergent SH2 domain that binds to the phosphorylated tyrosine; a four-helix bundle (4H) which packs against the SH2 domain and completes the phosphotyrosine binding pocket; and a calcium-binding EF-hand, which wedges between the SH2 and 4H domains [10].

In all cases, a big tunnel coinciding with the substrate binding pocket and a second putative tunnel that may be an exit for the release of the reaction products can be observed.

This is achieved through a bipartite binding site that consists of a phosphotyrosine binding pocket and a pocket or groove for specific residues that are carboxyl-terminal to the phosphotyrosine.

The P-loop is seen forming the SO4 2− binding pocket and an Mg2+ is observed coordinated by T227, K231 from P-loop and E345 from motif II (Fig. 1E).

This protein consists of a flavodoxin-like FMN-binding domain that is connected to a cytochrome p450 reductase-like domain, including a FAD binding pocket and an NADP(H) binding site (Fig. S5).

This finding was supported by analysis of the binding pocket consensus of the promiscuous PDZ cluster, which revealed the preference of a histidine residue at position 14 (αB1, present in 80% of the binding pockets) and a valine at position 16 (αB5, present in 70% of the binding pockets; Fig. 4C panel b).

PaCoaA has a fully enclosed pantothenate binding pocket and requires a monovalent cation to weakly bind ATP in an open cavity that does not interact with the adenine nucleotide.

In biological fluids, SHBG exists as a homodimer with a separate steroid-binding pocket and a calcium-binding site in each monomer [ 20] and binds to both androgens and estradiol with nanomolar affinities [ 21].