DXPas34 is a well-characterized tandem repeat that serves as a binding platform for multiple transcription factors and contains bidirectional enhancing properties essential for the expression of Tsix, the antisense transcript of Xist (Debrand, Chureau et al. 1999, Cohen, Davidow et al. 2007, Donohoe, Zhang et al. 2007, Navarro, Oldfield et al. 2010, Gontan, Achame et al. 2012).
DXPas34 is a well-characterized tandem repeat that serves as a binding platform for multiple transcription factors and contains bidirectional enhancing properties essential for the expression of Tsix, the antisense transcript of Xist (Debrand et al., 1999; Cohen et al., 2007; Donohoe et al., 2007; Navarro et al., 2010; Gontan et al., 2012).
The modifications create binding platforms for different chromatin modifying enzymes as well as proteins with structural functions in chromatin formation.
EJC provides a binding platform for factors involved in mRNA splicing, export and non-sense mediated decay (NMD).
Alternatively, histone phosphorylation might create a direct binding platform for these proteins [ 35].
Epigenetic mechanisms controlling transcription activation and repression include DNA methylation and post-translational modifications of histones, which can affect the architecture of chromatin and/or create 'docking platforms' for multiple binding proteins.
WD40 domains can thus act as large interaction platforms for multiple protein interactions.
How can we create a platform for multiple voices?
New machines are often more a platform for multiple techniques than a simple dialysis monitor.
SATB1 organizes chromatin into loops through binding of base-unpairing regions, which are found in gene-rich regions, and can regulate a large number of distally located genes by functioning as a landing platform for multiple chromatin remodeling/modifying proteins that confer specific epigenetic marks [ 78].
