Further study confirmed that H3S10 phosphorylation provides a binding platform for the phospho-binding 14-3-3 14-3-3 14-3-3histone acetyltransferase MOF to trigger acetylation of histone H4 at lysine 16 (H4K16ac), and H3S10 proteinsylandon and histone further coordinacetyltransferasethe binding site for broMOFomain protoin BRD4 (Zippo etrigger2009).
It can either constitute a binding platform for the regulators of transcriptional machinery or temporarily interfere with the binding or activity of factors targeted to adjacent residues.
Nucleosomes containing H3K27me3 provide a binding platform for the recruitment of the PRC1 complex containing PHC, CBX, BMI1 and RING1A, RING1B (RNF2) and MEL-18 (PCGF2) via the affinity of chromodomain containing proteins to these PTMs.
Another advantage is that SLX4 may function not only as the binding platform for the endonucleases, but also as a coordinator, orchestrating complicated processes at telomeres in a regulated manner.
These findings, along with a comparison of the structural data, indicate that loop 2 configures a binding platform for the acceptance of the incoming primer strand, which is remodeled to the "open" conformation during the assembly of the preternary complex to direct the arrival of the primer terminus into the active site.
Sin3 associates with RBP2 (retinol-binding protein 2) through SAP30 (Sin3-associated protein 30) and recruits histone methyltransferase Suv39H1 (suppressor of variegation 3 9 homologue 1) that results in trimethylation of hypoacetylated H3K9 and provides a binding platform for the chromodomain of HP1 (heterochromatin-binding protein 1) protein [ 10, 37, 53, 54].
An explanation for the ordered binding of Snu13 and Prp31 was provided by structural studies that showed how hSnu13 and the hU4 5′SL provide a composite binding platform for the hPrp31 Nop domain (Liu et al., 2007, 2011), while the mechanism by which hSnu13 leads to enhanced interaction of hPrp3 with U4/U6 di-snRNAs (Nottrott et al., 2002) remained enigmatic.
The protein is a homotrimeric, ring-shaped molecule that encircles DNA and acts as a binding platform for the replicative DNA polymerases as well as components of other pathways involved in DNA repair, chromatin dynamics and cell cycle regulation (Kelman 1997).
These molecules act as highly specific binding platforms for the recruitment of effector proteins to specific membrane compartments.
Analogously, it is possible that a GW182 PABPC1 complex might provide a binding platform for additional interactions required in silencing; these could include interactions with the CAF1 CCR4 NOT1 deadenylase complex.
