Sentence examples for binding platform for the from inspiring English sources

Further study confirmed that H3S10 phosphorylation provides a binding platform for the phospho-binding 14-3-3 14-3-3 14-3-3histone acetyltransferase MOF to trigger acetylation of histone H4 at lysine 16 (H4K16ac), and H3S10 proteinsylandon and histone further coordinacetyltransferasethe binding site for broMOFomain protoin BRD4 (Zippo etrigger2009).

It can either constitute a binding platform for the regulators of transcriptional machinery or temporarily interfere with the binding or activity of factors targeted to adjacent residues.

Nucleosomes containing H3K27me3 provide a binding platform for the recruitment of the PRC1 complex containing PHC, CBX, BMI1 and RING1A, RING1B (RNF2) and MEL-18 (PCGF2) via the affinity of chromodomain containing proteins to these PTMs.

Another advantage is that SLX4 may function not only as the binding platform for the endonucleases, but also as a coordinator, orchestrating complicated processes at telomeres in a regulated manner.

Sin3 associates with RBP2 (retinol-binding protein 2) through SAP30 (Sin3-associated protein 30) and recruits histone methyltransferase Suv39H1 (suppressor of variegation 3 9 homologue 1) that results in trimethylation of hypoacetylated H3K9 and provides a binding platform for the chromodomain of HP1 (heterochromatin-binding protein 1) protein [ 10, 37, 53, 54].

An explanation for the ordered binding of Snu13 and Prp31 was provided by structural studies that showed how hSnu13 and the hU4 5′SL provide a composite binding platform for the hPrp31 Nop domain (Liu et al., 2007, 2011), while the mechanism by which hSnu13 leads to enhanced interaction of hPrp3 with U4/U6 di-snRNAs (Nottrott et al., 2002) remained enigmatic.

Alternatively, histone phosphorylation might create a direct binding platform for these proteins [ 35].

These molecules act as highly specific binding platforms for the recruitment of effector proteins to specific membrane compartments.

Our results establish that the CRISPR system can be used as a modular and flexible DNA-binding platform for the recruitment of proteins to a target DNA sequence, revealing the potential of CRISPRi as a general tool for the precise regulation of gene expression in eukaryotic cells.

Our results show that dCas9 can be used as a customizable RNA-guided DNA-binding platform for the regulation of gene expression at natural and synthetic promoters in eukaryotic cells.

The exosome is then thought to function by the core ring structure serving as a binding platform for proteins targeting the exosome to various substrates and to channel the RNA to the active sites of Rrp44/ Dis3 (Bonneau et al. 2009).