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Or is life-threatening malaria linked to specific binding phenotypes that can target IEs to vital organs such as the brain, or cause particularly severe microvascular obstruction?
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We then examined whether GPM1 could influence the cellular phenotypes that can influence SLE-like phenotypes.
Conclusions: Individuals with FAS and PFAS have a distinctive facial phenotype that can be characterized anthropometrically.
There is, however, no platelet phenotype that can be used as a direct diagnostic biomarker for migraine [180].
Focusing on MCF7, a breast cancer cell line that adopts cancer stem-like phenotypes when grown under specific conditions, the authors demonstrated that different growth conditions give rise to distinct lectin binding profiles that can distinguish these cancer cell subpopulations [9].
If the generation of the phenotype requires binding of SH2-domain effectors that can interact with only one phosphorylated RTK, then expressing a DN mutant of one RTK in the presence of a CA mutant of another RTK should still cause complete or almost-complete suppression, returning the embryos to a near-wild-type TC/LT phenotype.
Although CSA binding property represents the major specific phenotype of placental parasites that can be reproduced in laboratory-adapted parasite lines in vitro, some characteristics of parasites causing PAM might require in vivo conditions for expression.
Expressing either an N-WASP mutant that is able to interact with Cdc42 but lacks the Abp1-binding PRD or expressing an N-WASP mutant that can undergo Abp1 binding but lacks the Cdc42 binding N-terminal part also caused phenotypes similar to that of Arp2/3 complex inhibition, Arp3 RNAi or Abp1 RNAi.
Supportive phenotypes (e.g., metabolites) are parameters that can be assumed to have some functional relationship with the key phenotypes.
Finally, species differences are also a vital factor that can affect the binding of active components binding and plasma proteins.
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