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Alternatively, some of these genes may only be regulated in vivo, a condition that cannot be recapitulated by in vitro cell culture model, even though the GR binding phenotype is conserved in 3T3-L1 adipocytes.
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This phenotype is conserved in the selective TAp73 [14] and ΔNp73 [15] knockouts mice.
Furthermore, while key cellular phenotypes are conserved they manifest in distinct behavioural dysfunction.
This indicates that even though the binding location of DB00631 fluctuates with different peptides, the overall binding affinity is conserved.
Furthermore, an Rbpjκ binding site is conserved on the promoters of Nrf2 among animal species.
Further analysis of this binding site reveals that the YopJ binding site is conserved in other MKKs.
All positions are not highly conserved; however the hydrophobic nature of the binding site is conserved.
The Norrin Fz4CRD binding interface is conserved between the complex structures.
The binding site, M3, is conserved in 8 of them.
The C8γ-binding cysteine is conserved in the perforin-like domain.
In the case of pdc2Δ344 the DNA-binding and transactivation site are both intact, whereas in pdc2Δ519 only the DNA-binding site is conserved.
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