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The DNA of candidate phages can be recovered and sequenced, elucidating positive binding peptides that can then be synthetically fabricated in large quantities at relatively low cost.
However, this enzyme also deamidates gluten peptides, resulting in high affinity HLA-DQ2/8 binding peptides that can further increase T cell responses.
In addition, modification of gluten peptides by the enzyme transglutaminase results in high affinity HLA-DQ2/8 binding peptides that can induce T cell responses [ 15, 16].
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A recent study identified a small peptide that can interfere with Nck binding to Pak1, which can interfere with angiogenesis [ 48], suggesting that small molecule interference of PAK interaction with its binding proteins may have some therapeutic value.
These results indicate that HMGB1 has two LPS-binding peptide regions that can be utilized to design anti-sepsis or LPS-neutralizing therapeutics.
Both classes of HLAs have a long binding groove that can bind peptides degraded from antigens.
Different HLA alleles have different binding affinities for peptides (epitopes) that can fit in their HLA peptide binding site.
Computational methods can assist by predicting peptide-MHC binding affinities that can later be experimentally validated.
The current structures and functional data reveal a binding site that can accommodate peptides in different orientations that helps to explain the broad substrate specificity characteristic of this pharmaceutically relevant transporter family.
This study reveals that polyspecificity in the POT family is likely to have arisen in part through the evolution of a binding site that can accommodate peptide ligands in at least two different binding modes.
Albumin has binding pockets that can capture fatty, hydrophobic molecules, so the researchers added a fatty tail called a lipid to their vaccine peptides.
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