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Significant binding peaks were defined as probes containing four or more signals above background in a 500 bp sliding window; the degree of significance depended on the FDR value.
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Cancer-specific methylation peaks were defined as hypermethylated regions.
From this background protrude several distinct spectral peaks [17], [18], as many as fifteen depending on how peaks are defined.
A putative peak was defined as a 150 bp window whose peak z-score was >60.
As stated above, an ARISA peak is defined as one electrophoretic peak in an ARISA profile.
The peak height was defined as the maximum thrombin concentration.
The binding peaks were determined by the peak finding algorithm provided in the TiMAT package.
GATA1 binding peaks were obtained from [ 15].
This analysis showed that 23.8% of all FXR binding peaks were located close to LRH-1 peaks.
Our results showed that 18% for ChIP-seq, 44% for ChIP-PET, 45% for ChIP-chip of Pol-II binding peaks are located within Promoter regions (defined as 2 kb upstream to 2 kb downstream, including 5' Core, 5'TSS and WithinGene Core regions) of a known transcription start site (5'TSS) (Additional file 1, Table S1 and Additional file 2, Figure S1).
Start and end coordinates of the binding sites were defined as the positions were the number of reads reached 50% of the peak height.
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CEO of Professional Science Editing for Scientists @ prosciediting.com