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Second, many LAD borders coincide with a binding peak of one of the insulator proteins.
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For a TF, target genes are defined as those with at least one binding peak of the TF in its promoter regions (from 1000 bp upstream to 500 bp downstream of their TSS).
The SNP falls in the binding peak of c-Jun.
Humanity has reached its peak of one-way consumption. .
Non-central remodeling does not overlap the GR binding peak and affects the occupancy/position of one or more nucleosomes flanking the NDR (Fig. 4b, signal profiles).
Peak areas were normalized to the sum of all glycan peak areas of one sample.
To illustrate the difference of these two cell lines, we first compared the overlapped number of genes with ERα binding peak and Pol-II binding peak, respectively.
Furthermore, an AG binding peak was in the CRM4.
Further supporting this notion, Atrx-bound genes defined as those harboring one or more Atrx binding peaks within 10 kb of their TSSs (Supplementary Data 1)—were strongly enriched for transcripts differentially expressed in the context of Atrx deficiency (P = 4.5 × 10−149 ; hypergeometric test).
We quantify the overlapping level of binding peaks in two datasets d i for TF F i and d j for TF F j, defined as, 1 where | d i | and | d j | are the number of binding peaks in d i and d j, respectively, and o i (d i, d j ) the number of sequences that have at least one pb overlap between the sequences in the two datasets.
To quantify this we carried out overlap analysis of the binding peaks and found, for example, that 89 % of Ubx peaks overlap with Abd-A peaks (Fig. 1b).
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