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For strains with similar binding patterns within the same genogroups, such as Norwalk virus (GI-1) and C59 (GI-2) in the A/B binding group that both bind to types A and H antigens of secretors but not to the Lewis antigens of the non-secretors [22], such conservation is understandable.
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The target-site binding patterns within 3'-UTR of the LARP4 gene were identical between H. sapiens and M. musculus, although the similarity of the two 3'-UTR sequences was ~70% (data not shown).
To explore the functional consequences of different binding patterns within a local region, future work could incorporate RNA-Seq data into consideration.
We showed that strains with distinct HBGA binding patterns within genogroups share common receptor binding interfaces in their interactions with variable HBGAs, likely tuned up by subtle structural differences within the binding interfaces.
Methylation-specific protein binding patterns were found within the aryl hydrocarbon receptor repressor (AHRR) gene with the highest level of changes associated with tobacco smoking.
Taken together, these data demonstrate distinct binding patterns of the two rhAbs for epitope(s) within the HA1 domain of H5N1 viruses.
TIP-1 specific antibody competed with the HVGGSSV peptide for binding within irradiated tumors, and exhibited similar binding patterns as the peptide in tumor-bearing mice.
To test whether transcription factor clusters associate with transcribed genes, we investigated the binding pattern of clusters within the set of annotated nonredundant genes (that is, gene clusters; see Methods) and their promoters (that is, promoter clusters) and correlated this with RNA-Seq gene transcription data (see Methods).
The apparent lack of an enriched RBM47-binding motif within robust CLIP-derived binding sites may reflect the broad binding patterns observed, as exemplified by the predominantly 3′UTR binding in DKK1 and IL8.
Similar binding patterns were observed near the AGR3 gene.
In order to study the binding pattern, the binding sites of 12 selected miRNAs were mapped to HPV alignments.
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