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To explore the functional consequences of different binding patterns within a local region, future work could incorporate RNA-Seq data into consideration.
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We showed that strains with distinct HBGA binding patterns within genogroups share common receptor binding interfaces in their interactions with variable HBGAs, likely tuned up by subtle structural differences within the binding interfaces.
For strains with similar binding patterns within the same genogroups, such as Norwalk virus (GI-1) and C59 (GI-2) in the A/B binding group that both bind to types A and H antigens of secretors but not to the Lewis antigens of the non-secretors [22], such conservation is understandable.
The target-site binding patterns within 3'-UTR of the LARP4 gene were identical between H. sapiens and M. musculus, although the similarity of the two 3'-UTR sequences was ~70% (data not shown).
Methylation-specific protein binding patterns were found within the aryl hydrocarbon receptor repressor (AHRR) gene with the highest level of changes associated with tobacco smoking.
However, the binding patterns were measured on a qualitative basis.
Analysis of binding within bidirectional promoters revealed interesting binding patterns for CREB.
TIP-1 specific antibody competed with the HVGGSSV peptide for binding within irradiated tumors, and exhibited similar binding patterns as the peptide in tumor-bearing mice.
FTIR is a convenient tool to study the binding patterns of organic linkers and Co2+.
The apparent lack of an enriched RBM47-binding motif within robust CLIP-derived binding sites may reflect the broad binding patterns observed, as exemplified by the predominantly 3′UTR binding in DKK1 and IL8.
For each interval within 10,000-bp upstream of the mature microRNA, the probability that it contains a TSS was calculated by comparing whether the RPol II binding patterns in the surrounding bins fit the patterns deduced in the expressed coding genes (Eq 3), defined as ΔF.
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