However, different strains show different binding patterns, with the worldwide dominating genogroup II.4 strains expressing the broadest histo-blood group-binding pattern and thought to be able to infect secretor-positive individuals of all ABO blood group types irrespective of Le status [31].
At a later date Owen et al. reported the presence of three different binding patterns with PBR28 (high-affinity binding, low-affinity binding and mixed-affinity binding), whereas no difference in affinity of PK11195 for TSPO was found in their study [ 51].
Such an asymmetric binding pattern with incomplete dehydration is different from the observations in the potassium channels where the K+ ions are completely dehydrated and form strong coordination with eight symmetrically positioned carbonyl oxygen atoms of the protein (Zhou et al., 2001).
This binding pattern is different from the one obtained with the 1918 (SC/18 H1N1) pandemic strain, which binds exclusively to a specific subset of α2,6 sialylated oligosaccharides (including 6'SLN-LN) [17].
We examined the nucleosome occupancy profiles around TFBSs to better understand the intricate relationships between TF binding and chromatin structure, and we also investigated the correlations between binding sites with different patterns of nucleosome occupancy and gene expression.
In line 1 animals, transgenic mice expressing the human form of AVPR1A showed profoundly different binding patterns when compared with wild-type littermates (Figs 2, 3), a finding that was replicated in the second, independently-derived line (supplementary material Fig. S2).
Likewise, binding patterns of a specific mAb with different virus strains reveal information on their antigenic relatedness.
