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It is also unclear whether Zfp335 displays cell type-specific binding patterns, which may allow Zfp335 to fulfill various developmental roles by regulating different gene expression programs.
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The FDA-approved HIV protease inhibitors share same structural similarities and a similar binding pattern, which may cause some of the common side effects of the protease inhibitor-containing regimens.
The convergence of these two technical lines may be creating a pennant pattern, which may foreshadow another directional move upon a breakout or breakdown from this pattern.
In summary, this study effectively reveals combinatorial co-binding patterns which involve potential regulators in mouse ES cells.
Comparison of the three-dimensional structures in complex with MHC suggests major differences in hydrogen bonding patterns with H2Kb, despite sharing similar binding modes, which may account for the differences in affinity and immunogenicity.
Third, once the head domain finds a proper binding site on the actin filament, it initiates weak binding which may further progress into a strong binding between the F-actin and the head domain of myosin.
The other 15% mutations may impair substrate binding, which may indirectly still confer instability.
These molecules often contain adhesion-binding sequences, which may potentially be replaced by synthetic peptides.
Alternatively, the FCA and ABAP1 proteins provide an opportunity to elucidate the structure of an ABA-binding pocket, which may reveal important sub-domains and structural constraints for ABA binding.
Similarly, transcription termination involves the binding of multiple accessory proteins which may affect the pattern of mutations and repair at the 3'-end.
Activation of mouse CD4+ and CD8+ T cells leads to dramatic remodeling of terminal glycosylation patterns of N-glycans which may alter the recognition of activated and resting T cells by other cell types expressing glycan-binding proteins that recognize terminal sequences of N-glycans [9].
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