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To predict the genomic loci of microRNA transcription start sites, we applied the model on the RPol II binding patterns in the upstream region of all annotated microRNAs.
For each interval within 10,000-bp upstream of the mature microRNA, the probability that it contains a TSS was calculated by comparing whether the RPol II binding patterns in the surrounding bins fit the patterns deduced in the expressed coding genes (Eq 3), defined as ΔF.
This conclusion is further supported by our analysis of TF binding patterns in the modules of the Zhou et al network.
Using the same K-means clustering setting, we further separated ES and NP datasets into different H3K4me2 binding patterns in the extended TSS region.
To investigate whether hnRNP C interferes with U2AF65 binding to cryptic exons, we compared binding patterns in the knockdown and control samples.
As the whole of the upper respiratory tract are architecturally identical, characterised by ciliated pseudostratified squamous epithelia interspersed with goblet cells and subepithelial structures of mucous/serous glands, we expect lectin binding patterns in the nasal turbinate and larynx to be highly similar to the reported trachea and bronchus.
Similar(54)
Compounds 7, 8, 15 and 16 overlays showed similar binding pattern in the active site of MMP-2 protein as that of co-crystallized inhibitor.
The crystal structures of PolB alone and in complex with the substrate analogs 5-Br UMP and 5-Br dUMP showed that the methylation mechanism of UMP and dUMP might be similar because they adopt the same binding pattern in the active site of PolB.
The overlay of docked poses of compounds 7, 8, 15 and 16 with that of 4H3X ligand showed that the selected compounds had the similar binding pattern in the active site of MMP-9 protein as that of co-crystallized inhibitor (Figs. 8a, 9a, 10a and 11a).
The overlay of docked poses of compounds 7, 8, 15 and 16 with that of 1HOV ligand showed that compounds 7, 8, 15 and 16 had similar binding pattern in the active site of MMP-2 protein as that of co-crystallized inhibitor (Figs. 4a, 5a, 6a and 7a).
However, the factor binding pattern in the HE prior to the expression of RUNX1 is different.
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