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Studies that have tracked the evolution of different transcription factor (TF) binding patterns have shown that sequence evolution alone is incapable of fully explaining the evolutionary dynamics of TF binding landscapes (Dermitzakis and Clark, 2001; Birney et al., 2007; Borneman et al., 2007; Schmidt et al., 2010).
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Similar binding patterns have been shown in numerous studies on MCI patients using the 11C-PiB amyloid biomarker [38, 39].
The variable binding patterns have been further sorted into two major binding groups, the A/B binding group and Lewis binding group based on shared HBGA targets within binding groups.
To date there have been no studies that have shown similar cellular binding patterns of a KRAB domain containing protein and H3K9me3.
Previous studies have shown that motion patterns of the binding pocket play an important role.
These results are compatible with the work of Xu et al. 2004 [ 37], which have shown the same pattern of binding for ScaD [ZP_09464030] from A. cellulolyticus.
Recent bombings in Pakistan have shown a similar pattern.
International studies have shown similar half-hour patterns.
We have shown that the binding specificity for Ley by hu3S193 does not involve conformational changes and the interaction mimics the hydration patterns of free Ley antigens.
Studies have shown that Rad52 has a binding preference for 5′ or 3′ ssDNA ends, and ssDNA hypersensitivity to hydroxyl radical patterns suggests that four nucleotides are protected by Rad52 binding (49, 50).
In this example we have shown that quantitative weights of the "absolute" basis patterns can be used instead of individual histone modifications levels as independent variables in the prediction of Pol2 binding.
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