Sentence examples for binding patterns around the from inspiring English sources

Our model using RPol II binding patterns around the TSS appeared to accurately distinguish between expressed and unexpressed genes.

As our approach assumes that the distribution of RPol II binding patterns around the transcription start site (TSS) of microRNA and protein coding genes are similar, we first designed a statistical model to mimic RPol II binding patterns around the TSS of well-annotated promoter regions of highly expressed protein coding genes.

Using maximum likelihood estimation, we identified the parameters that best described RPol II binding patterns around the TSS of highly expressed, well-annotated promoter regions of protein-coding genes, and we then scanned the upstream regions of all the intergenic microRNAs, searching for genomic regions statistically similar to RPol II binding patterns around the TSS of the coding genes.

Based upon the assumption that the distribution of RPol II binding patterns around the TSS of microRNA and protein coding genes are similar, we designed a statistical model to mimic RPol II binding patterns around the TSS of highly expressed, well-annotated promoter regions of protein coding genes.

Using the model parameters estimated based on RPol II binding patterns around the transcription start sites of protein coding genes, we indentified 83 active microRNA promoters in HeLa cells (with false discovery rate ≤0.2, Supplementary Table S1).

These five factors each follow a Gamma distribution genome wide among all the expressed genes; therefore, we assume that the RPol II binding patterns around the TSS of expressed genes were determined by 10 Gamma parameters Φ (see methods).

Our data demonstrated that RPol II binding pattern around the gene transcription start site follows distinct patterns (Figure 2A), and our model is designed to jointly describe the number of RPol II binding fragments surrounding the TSS, including both promoter and transcript regions; this allows for a more accurate description of RPol II binding pattern features.

We have examined the RPol II binding pattern around the TSS of common protein coding gene and the bidirectional promoter region.

We previously developed a computational strategy to predict the promoter regions of microRNAs based on the RPol II binding patterns around their transcription start sites [22].

To evaluate whether the microRNA was actively transcribed, a false discovery rate (FDR) was calculated by comparing this score (ΔF) to the values derived using RPol II binding patterns around unexpressed genes.

ChIP-seq experiment revealed that RPol II followed distinct binding patterns around transcription start site of coding genes (Figure 2).