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Strikingly, at 10 μM, Compound 30 achieved a 99% impact, reducing AR binding essentially from maximum to minimum level with a binding pattern similar to that of R1881.
Characteristically, this turn exhibits a consensus binding pattern similar to GXGXXG, in which the first 2 glycines participate in NAD(P -binding, and the third facilitates close P -binding the helix to the betandthend.
These animals were shown to be an ideal model for transmission studies of H5N1 virus because H5N1 virus preferentially attaches to the lower respiratory tract in ferrets, a binding pattern similar to humans.
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To identify new recruiting proteins, we computationally screened for factors with binding patterns similar to the observed Tup1-Ssn6 genomic distribution.
We used this model to systematically scan the regions upstream of all intergenic microRNAs for RPol II binding patterns similar to those of TSS from protein coding genes.
Going forward, it will be important to demonstrate that primary human lung cancer samples exhibit SH2 binding patterns similar to those seen in lung cancer cell lines.
The objective of this study was to identify the TSS and promoter regions of pri-microRNAs by searching for RPol II binding patterns similar to those seen in expressed protein-coding genes in the upstream regions of annotated mature microRNAs (see methods for details).
Genomic annotation of MKL1 binding sites indicated a distribution pattern similar to SRF peaks.
Furthermore, transgenic mice harboring the prairie Avpr1a locus display ligand binding to AVPR1A in a pattern similar to that seen in prairie voles and also display increased pro-social behavior in response to an AVP challenge, as compared with wild-type mice (Young et al., 1999a).
We found that KAP1, a specific, high-affinity KRAB-binding protein[24], had an expression pattern similar to that of KRAB-ZFPs, inferring that KAP1 may assist KRAB-ZFPs in promoting FL hematopoiesis (Figure 5).
The B-WICH components exhibited a binding pattern more similar to that of the RNA pol I, and the activator UBF than to that of the silencing histone mark H4K20-me3 (Figure 1A).
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