We observed similar binding patterns for the mammalian influenza (H1N1) viruses, with the exception that the pandemic strains had reduced binding to chicken erythrocytes.
Moreover, pairwise correlation analysis of all genome-wide binding profiles followed by hierarchical clustering demonstrated that with the exception of CTCF, binding patterns for the TFs clustered by cell type rather than the paired HPC7/mast cell datasets for the same TF (Fig 2C).
We next analyzed our ChIP-seq data sets to identify the core transcriptional network that characterizes the cellular identity of t(8 21) cells by determining overrepresented combinatorial binding patterns for the transcription factors RUNX1/ETO, C/EBPα, HEB, LMO2, PU.1, and RUNX1 (Tijssen et al., 2011).
The results show that these two nsP3 domains share a similar binding pattern for accommodating the ADP-ribose.
This epigenomic analysis highlights a similar binding pattern for TRIM33 at the Bim locus in this cell type.
The probe binding pattern for each sample was scanned and the HLA-DRB1 genotype was assigned by the inhouse software StripScan.
The binding pattern for RKl-8 was confirmed with sera taken at different time points between 2003 and 2007 (data not shown).
The binding pattern for Myc that we found, however, is in agreement with previously reported location analysis of Myc binding sites in the human genome [ 33].
Interestingly, we observed the opposite binding pattern for NDE1 and NDEL1 with regard to DISC1 Ser704Cys, with a stronger affinity of NDE1 to DISC1-Ser704 toan DISC1-Cys704704 (Fig. 6D and E).
Fourthly, it fails to define a binding pattern for each identified differential binding site after comparing two samples.
