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In this work we report, for the first time, the use of a supervised molecular dynamics approach to explore the possible protein-peptide binding pathways within a timescale reduced up to three orders of magnitude compared with classical molecular dynamics.
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Immediate/interpersonal factors are the "mediating pathways" within a community.
Query 1. Find pathways within a given number of steps from a pathway.
Pathways within a given number of steps from a pathway: This query searches for pathways that are n reactions away from a given pathway.
In addition, the MBD forms a discrete dimer on DNA via a noncooperative binding pathway.
54, 55 Importantly, in considering structural elaboration based on any of these hits, the possibility of multiple binding modes within a compound class could provide the medicinal chemist with alternate pathways to optimized compounds.
Two separate pathways of DNA damage, an oxidative pathway and a metal-binding pathway, have been proposed to account for the lesions observed in cell systems.
LPA can regulate a variety of signaling pathways within cells by binding to G protein-coupled receptors located on the cell surface [30], and it was possible that the effects on PPARγ might be mediated by this type of pathway if the LPA synthesized by GPAT1 could cross the plasma membrane to leave the cell and then interact with LPA1 receptors present on the plasma membrane [24].
Space flows freely up and down staircases and ramps, creating multiple pathways within what amounts to an interior landscape: a fixed but flowing garden of sculptural void.
This binding initiates a signalling pathway within the cancer cells which favours tumour growth, activating mitogenesis and inhibiting apoptosis 87.
These analyses demonstrated that genes associated with Wnt signaling pathway components and interacting proteins are prominent in binding regions within 50 Kb of a TSS associated with expressed genes from ECC-Limb shared Twist1 binding peaks.
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