Sentence examples for binding partners to be from inspiring English sources
Although ErbB proteins were the first binding partners to be identified, Lrig proteins are also able to interact with other receptor tyrosine kinases that share no homology with the ErbB ectodomain.
Under these specialized conditions, one might intuitively expect diffusion of both binding partners to be slowed, as the authors suggest.
(i) They adopt a stable rigid fold, allowing binding partners to be engaged in a sequential and compartmentalized fashion, or (ii) they are intrinsically unstructured, plastic segments that sample the environment allowing for transient interactions.
Based on the hypothesis that the highly conserved intracellular sequence suggests both a required function for this domain and a potential for its binding partners to be conserved, we decided to identify LINKIN interactors by mass spectrometry using a human cell line.
At least 20 proteins (besides G-alpha subunits) have now been identified as direct binding partners for RGS proteins, and additional binding partners remain to be found [ 4].
With only tens of amino acids per tail and substantially more interactors, access of cytoplasmic binding partners to the integrin tail must be finely tuned and carefully regulated.
First, the degree of amino acid sequence conservation is increased within binding epitopes; secondly, the interfaces on two binding partners seem to be coupled in evolution, and thus can be used to predict binding epitopes and partners [ 52, 53].
Yet, assuming sponges are sister to eumetazoans, the few innovations that came with the origination of nervous systems were novel binding partners to an existing scaffold (Table S3).
Moreover, the function of several SLP65 binding partners remains to be elucidated.
However, it is likely that further UBE2QL1 binding partners remain to be identified and their role in RCC tumorigenesis elucidated.
However, the existence of such hypothetical intracellular TLR1- or TLR6-specific binding partners remains to be established.
