Sentence examples for binding partners such that from inspiring English sources

FGFR4 is expressed as a single FGFR4-IIIc isoform resulting in increased selectivity in relation to its FGF binding partners such that, in the absence of the single transmembrane containing co-factor β-Klotho, only FGF19 can bind to FGFR4 and initiate its downstream signal transduction pathways.

In addition, SNTA1 and P66shc share many binding partners, such as Sos1, Grb2, that have also been implicated in the Rac1 activation pathway.

In addition, we have shown that binding partners such as USP39, can activate USP4 function by binding to the Ubl domain (Fig 5C).

This action could be due to the interaction between this intracellular fragment and cytoplasmic binding partners, such as the LIM kinase1/LIMK1 [ 28] that is able to shuttle between the cytoplasm and the nucleus, by regulating gene transcription through interaction with the actin cytoskeleton [ 39].

Evidence is starting to surface that they might compete for binding partners, such as integrins, thus forming protein complexes with different biological consequences to cell behavior [ 18, 19].

Most such pathways are poised to influence the expression of select genes, a process that is primarily regulated by transcription factors and, very likely, other functional binding partners, such as chromatin-remodeling enzymes.

One possibility is that differential phosphorylation events can modulate the role it plays in a cell by altering its affinity for DNA or binding partners, such as c-Jun.

This unforeseen observation indicated that AKAP79 not only controls access to substrates but also influences how binding partners such as PKC respond to certain pharmacological inhibitors [ 20].

We can hypothesize that in our model, the formation of round colonies observed in 3D matrigel when Y477F ezrin is expressed could be due to the lack of interaction with binding partners such as Fes.

It is also possible that in many instances MYCN is not binding directly to DNA sequences, but instead is interacting with another DNA binding partner, such as a methyl binding protein.

Although we cannot exclude the possibility that unexpected Dvl-binding proteins may exist in the predicted data [ 97], no known Dvl PDZ-binding partners such as Dapper [ 65] and Daple [ 110] have been found in this data set, highlighting the importance of further verification of the proposed binding partners by other methods.