Sentence examples for binding partners such as from inspiring English sources

Our findings are consistent with a novel model in which CD44 palmitoylation facilitates its sequestration within lipid rafts, restricting its availability to bind to pro-migratory binding partners such as ezrin and thereby restraining tumourigenic behaviour.

These motifs are known to bind the end binding homology (EBH) domain of EB1 in +TIP binding partners such as CLASP, APC and CDK5RAP2 (Honnappa et al., 2009) (supplementary material Fig. S5).

The N-terminal Src homology 3 (nSH3) domain of a signaling adaptor protein, CT-10 regulator of kinase II (CrkII), recognizes proline-rich motifs (PRMs) of binding partners, such as cAbl kinase.

The flexibility of this groove might be necessary to accommodate different binding partners, such as N-CoR or Ski-interacting protein (Skip) [32].

In fact, the dimerization domain of MST1/2 mediates MST1 kinase activity by interacting with binding partners such as RASSF1A and hWW45 [51], [51].

The peptides were fused to their respective SH2 domain binding partners such as the N-terminal SH2 domain of mouse PLCγ1 for Y132 and the SH2 domain of mouse Grb2 for Y175and Y175and6].

It is also possible that in many instances MYCN is not binding directly to DNA sequences, but instead is interacting with another DNA binding partner, such as a methyl binding protein.

However, its most likely location is attached to a known binding partner such as intersectin.[14] Since many complexes involve linear protein arrays, an alternative and, as it turns out, more useful working model is to arrange the co-IP-proteins in a linear sequence according to their FR values (Fig. 3G).

As shown above, when hTTP was co-expressed with CIN85, the hTTP protein had an apparently greater Mr than the protein expressed alone, or expressed with another binding partner such as PABP (Fig. 2A2, lanes 4 and 6, Fig. 4D3, lane 2, Fig. 4E1, lanes 4 and 7, and Fig. 6A1, lane 4), suggesting that hTTP is hyper-phosphorylated in response to its interaction with CIN85.

However, it remains unclear at present whether the Gab2/STAT5 interaction is mediated via a direct interaction or via a mutual binding partner such as p85.

We detected Ser-286 phosphorylation in HEK293 cells through mass spectrometric analysis of exogenous Gro/TLE1 without the need for co-transfection of DNA-binding partners such as Hes1.