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The present structural results convey a simultaneous description of both binding partners of an LRP ligand complex and open a route to a broader understanding of the binding specificity of the LRP receptor, which may involve a general four-residue receptor ligand recognition motif common to all LRP ligands.
Identifying the binding partners of an unknown protein may shed light into its potential biological function.
The binding partners of an enzyme define its sites of action and regulatory mechanisms.
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Based on this general principle, the assay is designed to detect and identify protein binding partners of a protein complex.
Furthermore, using a peptide pulldown approach in combination with stable isotope labeling in cell culture (SILAC) we identified SLP-76, PLCγ, PIK3R1, Nck, CRK, Gads, and RasGAP as phospho-dependent binding partners of a central YDDV motif of ADAP.
All the binding partners of a biomolecule are listed on the 'Biomolecule Report' page.
With affinity purification and mass spectrometry, binding partners of a protein can be interrogated in an untargeted fashion, offering important insight to protein function [ 75].
Further, we propose that our in vivo overproduction system could be exploited as an efficient tool to identify the binding partners of a protein.
Specifically, the model predicts (i) a broad distribution of the connectivities (i.e., the number of binding partners of a protein) and (ii) correlations between the connectivities of interacting proteins, a specific consequence of the asymmetry of the link dynamics.
Bora was first identified as a binding partner of Aurora A in Drosophila (Hutterer et al. 2006).
One of the main binding partners of bacterial PDF is a trigger factor, a chaperone.
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CEO of Professional Science Editing for Scientists @ prosciediting.com