We also identified an additional 4 binding partners, including the single PDZ domain containing STN-2, a gamma syntrophin, and MPZ-1 that can be found at synapses.
Following activation by EGF-induced dimerization and autophosphorylation, EGFR recruits a group of binding partners including the scaffolding protein Grb2 to transmit proliferative and other signals.
ELF3 is known to have a number of binding partners, including the red-light photoreceptor PHYB, the ubiquitin E3-ligase COP1, and clock-related proteins GI, SVP, and CCA1, suggesting that ELF3 may function in large signaling complexes.
A second group of Ena/VASP binding partners, including the formin-family protein Diaphanous (Grosse et al., 2003; Schirenbeck et al., 2006; Barzik et al., 2014; Bilancia et al., 2014) and the WAVE regulatory complex (Law et al., 2013; Chen et al., 2014), relies on a related, but lower affinity, EVH1-binding motif: LPPPPP.
Mutation of Ser-286 to alanine or glutamic acid does not perturb the interaction of Gro/TLE1 with DNA-binding partners, including the basic helix-loop-helix transcription factor Hes1, a prototypical anti-neurogenic WRP(W/Y) motif protein.
Examples of these binding partners include a component of the exocyst complex, Sec3, to regulate directional cell migration, and protein interacting with C kinase 1 (PICK1) to regulate the trafficking of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors, the major excitatory neurotransmitter receptors in the brain.
Human APPL1 and APPL2 are homologous RAB5 effectors whose binding partners include a diverse set of transmembrane receptors, signaling proteins, and phosphoinositides.
Known binding partners include cJun, JunB, CEBP-γ and Ddit3 [ 60].
KIAA0586 (TALPID3) binding partners include PCM1, Cep120, and CP110, which interact with a known JBTS protein, CEP290 (Tsang and Dynlacht, 2013).
Apart from c-Src and adhesion junction proteins, other connexin binding partners include tubulin, caveolins, and zonula occludens-1 (ZO-1).
