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The results presented here indicate that binding partners in different transient functional complexes have certain general physicochemical properties in common, which could then be responsible for their colocalization or clustering on the microscopic level, and thus indirectly facilitate their binding.
One possibility is that Cdh7 has different binding partners in different tissues.
Interestingly, as described above, RACK1 can be associated with different binding partners in different brain regions.
In systems like ubiquitin that interact with different binding partners in different conformations, our approach can be used to introduce selectivity, as shown here.
RBBP4 and RBBP7 are found in many corepressor complexes such as SIN3A, PRC2 and NURF, and the two distinct binding sites would increase their ability to recruit alternate binding partners in different settings.
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The roles played by some of the PARP-1 fragments and their associated binding partners in the control of different forms of cell death are also discussed.
Most proteins bind their binding partners in the native confirmation.
Alternatively, the binding partners in such species may be different from those in humans.
Although analysis of the protein complexes in lower concentrations will give a worse signal-to-noise ratio, observed changes in the ratios of the complexes seen might give indications of the affinities of the different binding partners in these complexes.
Due to the structural and charge differences in their very C-terminus, the two main merlin isoforms are likely to have different binding partners in cases where the C-terminus is necessary for protein-protein interactions.
We also noticed that in some metazoa and the fungi phylum Basidiomycota the PACT domain-containing γ-TuCRs (such as AKAP9 in human and D-PLP in Drosophila) have N-terminal regions distinctive from SPM and CM1 motifs, probably reflecting different binding partners in γ-TuRC.
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binding partners in cultured
binding partners in oral
binding partners in complex
binding partners in binding
binding affinities in different
binding partners in such
binding partners in close
binding elements in different
binding partners in high-throughput
binding proteins in different
binding sites in different
binding modes in different
binding partners in non-treated
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