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NCS-1 is a multispecific protein interacting with a number of binding partners in both calcium-dependent and independent manners, and acting in a variety of cellular processes in which it has been linked to a number of disorders such as schizophrenia and autism.
As a molecular chaperone, hHR23a regulates the lifespan of its binding partners in both agonisticly and antagonistically.
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Most proteins bind their binding partners in the native confirmation.
Finally, to prove the binding of A38 to VACV with both binding partners in solution, corresponding to in vivo conditions, Fluorescence Correlation Spectroscopy (FCS) was performed (Fig. 3c).
There are moonlighting proteins that can both activate and inhibit their binding partners in the same or overlapping binding regions which have been found to be disordered.
Cotelle, V. et al. 14-3-3s regulate global cleavage of their diverse binding partners in sugar-starved Arabidopsis cells.
These studies reveal mechanisms and antagonistic partners for specific IAPs, and provide a powerful technology for labeling binding partners in transient protein-protein complexes.
The molecular mechanisms underlying Golgi localization of isothiouronium-modified compounds were investigated using 7 CHO and 4 human cancer cell lines and the results indicated that the compounds had binding partners in the Golgi.
A micro-fluidic immobilisation device allowing the covalent attachment of up to 16 binding partners in a linear array on a single surface has been developed for compatibility with a prototype multiplex SPR analyser.
The fluorescence arm of the screen, however, would detect binding partners in pools containing pore blockers.
Moreover, the literature supports the role of 14.3.3 proteins in cleavage of their binding partners in sugar-starved cells [71].
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