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One model allows for subfunctionalization in addition to dosage balance (consistent with a protein interacting with its different binding partners at different times), whereas a second excludes subfunctionalization (consistent with a protein that functions in a complex).
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NHERF1 is a PDZ-domain adapter protein that stabilizes its binding partners at the plasma membrane.
Furthermore, different relatives are binding diverse partners at different remote sites.
Do FOXP3 IRF4 complexes bind at different sites to FOXP3 GATA3 complexes and do the different binding partners lead to different local histone modifications and associated changes in gene activity?
Party hubs interact with most of their partners simultaneously, whereas date hubs bind different partners at different times or locations [ 15].
We identify Nup153 as an important impβ binding partner at the nuclear face of the pore.
Similarly, when considering an individual relative with multiple protein partners, it may be beneficial to have these partners binding at different sites, to reduce cross effects, unless binding to a common site was somehow important for regulation.
Disordered regions allow proteins to have many binding partners and different functions based upon the conformations.
Interestingly, as described above, RACK1 can be associated with different binding partners in different brain regions.
One possibility is that Cdh7 has different binding partners in different tissues.
The phosphorylation of β-dystroglycan on tyrosine acts as a molecular switch to regulate its interactions between different potential binding partners and different cellular adhesion functions (28).
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