There are no known binding partners that would interact with the periplasmic domain of AmtB.
Thus, we identified nuclear FAK binding partners that can interact, directly or indirectly, with five of the six main regulatory elements reported to control transcription of Ccl5 in multiple cell types (Fessele et al., 2002).
Although we utilized only a small fragment of FUS of 51 amino acids as bait, we were able to identify 24 putative binding partners that differentially interact with one or another of the two forms of the C-terminal peptide.
By identifying the host's binding partners that interact with the core proteins of the Japanese encephalitis virus (a mosquito-borne pathogen), insights were gained into how this pathogen co-opts the host's cellular machinery to ensure propagation [ 42].
Also the extension at the carboxy terminus of eIF4E-2b indicates eIF4E-2b and possibly eIF4E-2 interact with binding partners that are not associated with eIF4E-1 or −3.
In F-actin, the polar ends exhibit different growth and shrinkage rates and selectively interact with binding partners that affect filament protection or nucleation (Pollard and Mooseker, 1981; Wegner, 1982; Wang, 1985; Pollard, 1986; Selve and Wegner, 1986; Theriot and Mitchison, 1991).
Our data highlight UL141 as a non-TNF family protein that can interact with the ectodomain of the TRAIL DRs, providing further evidence for TNFR binding partners that extend outside of the canonical family.
Dystroglycan has been shown to interact with vinexin, a vinculin binding partner that resides in focal adhesions.
In addition to the non-DNA binding ligand-gated co-regulators, nuclear receptor activity can also be influenced by the binding of other DNA binding partner proteins that can interact with the nuclear receptors to form a cis-regulatory module to enhance or repress the transcription of select target genes [ 3].
The conformational selection model suggests that the protein exists in a dynamic equilibrium between major and minor species, and the binding partner selectively interacts with the minor species leading to the formation of the protein ligand complex.
