We performed an assay in C. elegans based on the hypothesis that some of the binding partners of human LINKIN would also be conserved in C. elegans.
Similarly, for LR11/SorLA, a binding partner of the human amyloid precursor protein, a H N-TROSY spectrum recorded in isotropic bicelles was used as a 'gold standard' in screening for a suitable detergent system.
In addition, RACK1 was pulled out in a yeast two-hybrid screen as a binding partner of the first PDZ domain of the human Na+/H+ exchanger regulatory factor (NHERF1) [ 52].
Analysis of the protein sequence of human cyclin Y, a cognate binding partner of PCTAIRE-1 necessary for its activation [ 5, 6], identified two proline-directed serine residues (S-P motif; Figure 1A).
A screen of a human aorta cDNA library revealed SESTD1 as a binding partner of TRPC4 and TRPC5 (Miehe et al. 2010).
Here, we provide evidence that human brain endothelium expresses integrin α-4/β-1, the molecular binding partner of sVCAM-1, and that sVCAM-1 directly impairs BBB function by inducing intracellular signalling events through integrin α-4.
In contrast, phylogenetic analysis of the gene, which encodes the p40 subunit of IL-23 and the binding partner of IL-23 p19, IL12B, revealed some (although minor) evolutionary divergence between the common transcript for both humans and chimpanzees (Fig. 2B).
TEAD family transcription factors are the major binding partner of TAZ in the nucleus.
Also β-catenin, an important binding partner of E-cadherin, was processed.
Also, OGT and HCF1 were characterized as major cellular binding partner of THAP1, a sequence-specific DNA binding factor (Mazars et al., 2010).
