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On the other hand, two single mutations (S346A and T347A) did not affect the binding outcomes.
The β-Gal of the precursor makes a major contact with the "bottom" of the binding interface, which is stabilized by residue T397, while the Le epitope, the α-1,3/4 Fuc (Le Fuc), contacts with another part of the "bottom" and is stabilized by the other "wall" (S346′, T347′, G348′ and D349′) to support the binding outcomes (Figs. 5D, 6 and 7D).
In fact, the H epitope of the Leb and Ley antigens played a minor role in the binding outcomes as it does not at all participate in binding to Ley, or interacting with the Leb through a single H bond among the eleven H bonds in total.
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At Durban, those arguing for a legally binding outcome won.
The poorest nations wanted a legally binding outcome by the end of next year.
Arbitrators – or organizational leaders playing the part of arbitrators – listen to each side of the conflict and then unilaterally decide and announce a binding outcome.
South Africa therefore is committed to continuing its engagement in the UNFCCC processes in order to be able to achieve in Mexico in 2010 the legally binding outcome that we had hoped for in Copenhagen".
Without parallel court proceedings to enshrine any agreement in an order of the court, there is no legally binding outcome from mediation at all.
Some developing countries, certainly the Alliance of Small Island States (AOSIS), but also South Africa and Brazil, supported a double protocol approach with a legally binding outcome in the AWG-LCA.
Its 2006 statement effectively served as a "reservation" against any binding outcome of UNCLOS's grievance procedure in the future.
The PRC's 2006 statement effectively served as a "reservation" against any binding outcome of UNCLOS's grievance procedure in the future.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com