Sentence examples for binding orientations are from inspiring English sources
The results presented in this study demonstrated that the binding orientations are similar among all TLRs; however, the residual interactions with their partners are specific.
As expected, physicochemical properties (such as lipophilicity), electronic properties, and substrate binding orientations are all important factors to determine the microsomal clearance.
Like C55-PP, monoolein is a single chain lipid with a hydrophilic headgroup and we propose the observed binding orientation is representative of the native substrate complex.
Our rapid approach to determine a ligand binding orientation was employed to determine a PrgI co-structure in the same manner as described previously [24].
A similar binding orientation was subsequently reported as the structural basis for selective DYRK1a inhibition by harmine.
R osettaD ock is available as a web server (http://rosettadock.graylab.jhu.edu) but is limited to complexes for which the approximate binding orientation is known.
However, density for the motor domains in the N255K maps clearly indicates that a wild-type binding orientation is not achieved in either case.
On the basis of these simulations, we engineered CYP3A4 mutants I369F, I369L, A370V, and A370L, in which the productive binding orientation was expected to be stabilized, thus leading to increased turnover of CBZ to the 10,11-epoxide product.
Data indicate that the driving force for the inverted binding orientation is the occurrence of a steric clash between the bulky halogen of position 7 and the kinase hinge.
It leads to rather interesting questions pertaining to which was a consequence of what whether TF binding orientation was a consequence of a given spatial orientation of cis regulatory modules or if the spatial distribution of cis-elements is a consequence of specific TF binding properties.
Moreover, although the overall size of the Trp side chain is larger than that of Tyr, the latter more closely approaches the cyclopentenyl ring of 2. This might explain why the "flipped" substrate binding orientation is not observed when 2 is reduced by wild-type OYE 2.6 but can occur when Trp replaces Tyr78.
