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We propose that the control of binding orientation can influence the recognition of multivalent ligands.
The measured affinity for the interaction between FLIPr and C1q complex was different depending on the binding orientation.
This change may result from the different binding orientation of the acceptor caused by substitutions in the acceptor-binding site.
Effects of peptide mutations are found to be consistent with the suggested binding orientation.
A single dominant binding orientation causes the high affinity for neonicotinoids at the insect nAChR homologue.
X-ray and modeling studies were used to understand ligand binding orientation and observed affinity.
Like C55-PP, monoolein is a single chain lipid with a hydrophilic headgroup and we propose the observed binding orientation is representative of the native substrate complex.
X-ray of the ethylene linked compound 61 confirmed the predicted binding orientation of the scaffold in the p38 enzyme.
Docking study was performed to study the binding orientation and affinity of synthesized compounds on the ER-α enzyme.
Docking study was performed to study the binding orientation and affinity of synthesized compounds for RT enzyme.
Four mutants are then strategically designed to modulate membrane perturbative activity in a manner consistent with the proposed binding orientation.
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