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The detected patterns describe the conserved binding organizations that involve energetically important hot spot residues and are crucial for the protein-protein associations.
Further, by recognition of conserved spatial patterns of physico-chemical interactions, it rationalizes hot spots' cooperativity and elucidates the complex binding organizations of the protein-protein interfaces.
Moreover, it reveals the conserved chemical binding organizations, which are formed by the atomic interactions and can not be detected at the residue level.
Conservation of the spatial binding organizations at the level of physico-chemical interactions is important for the formation and stability of protein-protein complexes as well as protein and drug design.
Although the overall backbones of the compared SAGs can not be rigidly aligned in 3D space (see figure 2 in [ 62]), the chemical binding organizations of their complexes are similar.
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Among the genes that were involved in viral replication, those associated with Golgi vesicle binding, organization and biogenesis were overrepresented (see Supplemental Table S4).
Several methods for evaluating the degree of binding site organization in a host structure are presented.
These domains might be involved in Ca2+ binding, structural organization or nuclear signaling.
Overall, genes in clusters 1 through 5 (early clusters) have relatively high transcript levels at the beginning of meiosis, and these clusters are enriched for genes involved in early meiotic processes with functions such as nucleic acid binding, cytoskeleton organization, chromosome cohesion, and damaged-DNA binding.
The kinetic adsorption profile at the DNA gold nanoparticle (AuNP) interface is probed by following the binding and organization of thiolated linear DNA and aptamers of varying chain lengths (15, 30, 44, and 51 mer) to the surface of AuNPs (13.0 ± 1.0 nm diameter).
We examined the biological process and molecule function categories associated with motifs and find Pxx[S] significantly enriched in endomembrane system organization and GTPase binding, Txxx[S] enriched in cytoskeleton organization, and [T]xxxxxxxxxP to take part in regulation of cell cycle.
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CEO of Professional Science Editing for Scientists @ prosciediting.com