Sentence examples for binding or stability of from inspiring English sources
An intriguing possibility is that the expanded GAA triplet-repeat sequence, possibly via formation of a non-B DNA structure [3], [16], [39], may compromise the loading, binding, or stability of cohesin and thereby promote CTCF displacement.
However, GST-AMPKα did not form a complex with either the LKB1S431A or LKB1S431D mutants, suggesting that, in response to growth factors, the Ser428 residue would be involved in the binding or stability of the LKB1-AMPKα complexes (Fig. 4B).
Additionally, Figure 4A demonstrates that the co-chaperones HOP and Hsc70 co-elute within the void volume (fraction 10) in vehicle but not with KU174 treated samples providing evidence that KU174 disrupts the binding or stability of these co-chaperones in complex with Hsp90.
The AHR2 variant in Hudson River fish was characterized by a 2-amino acid deletion, just downstream from the PAS domain, that was proposed to alter the ligand-binding affinity or stability of the AHR2 protein in these fish.
In silico site directed mutagenesis has been widely used to identify critical residue(s) for binding of a ligand/substrate or stability of protein.
This indicates a potential disruption of protein interactions that could influence binding or the stability of binding.
The overarching theme then, borne out by further experiments on known fALS mutations, is that metal-free SOD1 is a cause of ALS, and that some mutants associated with the disease may be more prone to oligomerize in vivo due to alterations in metal binding or the stability of that binding (Banci et al., 2008).
A lack of cdTMPRSS6 in the conditioned medium of TMPRSS6 Y141C -transfected TMPRSS6 Y141C -transfecteda lacells proteolytic auto-activation of the mayateitherteindicatecreased binding stabilack of the catalytic domain to the rest of the proteolytice to the formation of an extra disulfide bond in the Y141C-mutated profein.
In this study, we vary the direction of the force to investigate the effect of ligand binding on the stability of maltose binding protein (MBP).
Based on the molecular docking, dynamic studies explain binding, compare stability of the ligand protein complexes, and enable determination of interactions important in the binding modes of the ligands".
