Within Plasmodium sp., a family of erythrocyte binding proteins (EBPs) with signature cysteine rich motifs is involved in binding to erythrocyte receptors for invasion of erythrocytes [1] [4] or sequestration of parasitized erythrocytes to endothelial cells [5] [7].
The expressions of several ATP binding cassette (ABC) transporters, including breast cancer resistance protein (BCRP or ABCG2) and ABCA3, are thought to be responsible for expulsion or sequestration of the cytotoxic drugs [23], [24], [12], [13].
EBER1 might regulate cell survival or growth through modulation or sequestration of its protein partners.
Overexpression of PiCdc14 may misregulate proteins through excessive dephosphorylation or sequestration of its substrates.
Macrophages are the main cell type responsible for the uptake, breakdown, removal or sequestration of antigens.
There is however evidence of direct TWIST binding to MyoD [ 33] or TWIST binding and sequestration of MEF-2 or E-proteins [ 34, 35].
This broad definition can take into account the consequences of multiple mechanisms such as binding and sequestration of cofactors, limiting their availability or the occupancy of transcription promoters by factors that contain inactive transcription domains and therefore act as repressors.
Indeed, the most abundant secreted proteins found in mosquitoes, ticks and triatomine bugs are involved in binding and sequestration of biogenic amines such as histamine, serotonin norepinephrine or adenosine nucleotides [ 102, 148- 150].
In other cell types, Id proteins act through either direct binding and inhibition of bHLH transcription factors or indirect inhibition of bHLH transcription factor function through binding and sequestration of their essential heterodimerization partners E proteins (including E47 and E12) (Norton, 2000).
Mammalian MTs are proteins with 20 invariant cysteines (Fig. 3A) which are responsible for the binding and sequestration of zinc (Zn), cadmium (Cd) and copper (Cu), among other metals.
