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Previous studies on HIV1 RT and Ty3 RT have shown that certain mutations do not necessarily affect polymerization and pyrophosphorolysis equally, suggesting that binding or positioning of the substrates in one direction or the other can be differentially affected [11], [21].
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Enzyme function involves substrate and cofactor binding, precise positioning of reactants in the active site, chemical turnover, and release of products.
An accessory RNA subunit R S evolves, driven by selection for increasingly efficient binding and positioning of aminoacyl- T complex on R L (Fig. 12).
In our binding mode, the positioning of the C-terminal tetrapeptide sequence differs considerably from the one proposed for cholecystokinin in earlier studies [43, 44].
If such a 3-dimensional structure is available, PepSite analyses the SLiM-binding domain for the likely binding position of the peptide, producing a putative binary complex and a score for the likelihood of the interaction.
FXR is known to accommodate a flexible ligand binding domain, where ligand binding changes the position of the AF-12 helix and thus the recruitment of co-activator or -repressor proteins.
It is also worth noting that almost at the same binding energy position of Pd3d, Au4d lines are overlapping [21].
The correlation between the lithiation state and x is supported by the binding energy position of the Si 2p peak corresponding to the Li Si alloy.
The C 1 s peak of a pure carbon sample (binding energy position of 284.6 eV) was used as reference material for the calibration of the XPS spectra.
The binding energy positions of the two peaks confirm the valence of Mo is +4, which is consistent with the previous report [17].
These regions are highly enriched for erroneously inferred transcription factor binding sites, positions of nucleosomes and regions of open chromatin.
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