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Based on our study, the double-generation gold nanoparticle construction of chip can support more coating areas for receptor CLEC5A and then, support more binding opportunities for DV.
It is also highly likely that the high level expression and the S-layer mediated display of the ligands compensated for any less than perfect folding by providing multiple binding opportunities.
Such sequences may serve to stabilise poly(A) complex assembly by providing alternative binding opportunities for components of the 3′end processing machinery (Supplementary Figure 5).
BKA is a relatively long and flexible molecule with only three carboxylic groups, providing fewer and weaker binding opportunities than CATR (Fig. S4).
Perhaps the endosome contains a variety of binding opportunities and lipid environments that offer new sorting opportunities, different from those of the plasma membrane.
Adenosine offers many binding opportunities: i) hydrogen bonding to its Watson-Crick edge, to its major and minor groove edges, and to its ribose hydroxyls, ii) aromatic stacking interaction potential on each face of the base, and iii) relatively few rotational degrees of freedom.
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Whether SRP completely dissociates from the ribosome would depend on the off-rate of the S domain relative to the next Alu domain binding opportunity within the translation cycle.
In the case of genome-based drug design, the double helical structure of DNA provides three binding mode opportunities for potential ligands.
When poverty constraints are binding, the opportunity cost of studying is too high and parents are due to send children to work rather than to school.
In this situation, the high affinity gap binding provides additional opportunities for the polymerase to bypass impediments in the template strand.
"They have a bevy of attorneys who understand the difference between a legally binding equal employment opportunity statement and some reference on their Web site," Ms. Cox said.
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