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The increase of the amount of APCO2− leads to an additional binding of two molecules of APCO2− with MVCA-C108+.
These data are consistent with the binding of two molecules of PvRBP2b(161–969) to the TfR1 Tf complex with macroscopic dissociation constants in the mid-nanomolar to low-micromolar range.
These results indicate that the cooperative binding of two molecules of HP0593 MTase is required to methylate DNA.
The binding of two molecules is a two-step process that starts with the molecular transport of ligand and receptor into proximity before the chemical binding reaction step.
The structural determinants revealed unique features of the binding of two molecules of the dual inhibitor in the active site of C-ACE.
The subunits FwdB and FwdD exemplify how binding of two molecules of molybdopterin dinucleotide cofactor (MGD) is achieved by the mutual work of two Rossmann-like (di nucleotide binding folds fused together.
Similar(52)
PA binds receptors tumor endothelial marker 8 (TEM8) and capillary morgenesis gene-2 (CMG2) on normal tissues, undergoes cell surface furin-mediated endoproteolytic cleavage and release of a twenty kilodalton fragment, oligomerization of the remaining sixty-three kilodalton PA portions to form heptamers, followed by binding of three molecules of LF or EF per heptamer [4].
A molecular mass of 30380.4±2.5 Da was obtained which corresponds to the binding of one molecule of LG100754 to the RARα monomer (ΔM = 396 Da).
We analyzed a network model for the binding and dissociation of two molecules.
The model of PET-16 binding to only one of two molecules in the asymmetric unit cell of the crystals is consistent with the 1 2 stoichiometry observed in the ITC analyses, suggesting that the observed crystallographic DnaK dimer that presents only one PET-16 binding site also occurs in solution.
Elhage et al. used repeated subcutaneous injections of a specific TNF/LT inhibitor (TNF-binding-protein; TNFbp) consisting of two molecules of the extracellular domain of p55 linked to a polyethylene glycol molecule, which binds with equal affinity to both TNF-α and LTα.
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