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Recent evidence has also implicated the PCI domain in the binding of two distinct yeast eIF3 subunits (eIF3a and eIF3c) to RNA [ 14, 15] although in humans the same subunits were found to bind to RNA (HCV IRES) through independent RNA-binding HLH motifs [ 16].
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The study also reports that binding affinities of two distinct fibril edges with respect to incoming Aβ peptides are different.
Contrary to this paradigm, cellulosomal cohesin-dockerin (Coh-Doc) pairs are believed to interact through redundant dual binding modes consisting of two distinct conformations.
Three binding attempts with each of two distinct LTA preparations were performed with very similar results.
This indicates that the residual apical localization observed for the GFP-Dia-N′ΔBD construct can be attributed to Rho1 binding, consistent with the notion of two distinct functional modules for Dia binding.
Like cruise control on a car, the entry of calcium through these ion channels is delicately fine-tuned by the opposing control actions of two distinct binding partners: calmodulin and calcium-binding-protein.
That palonosetron has two binding modes (one slowly dissociating and one persistent) is consistent with the possibility of two distinct binding sites.
These hosts are characterized by the presence of two distinct binding region in close proximity: the rigid π-donor cavity and the H-bond donor N-methylene-N′-phenylureido group inserted onto the upper rim of the calix[4]arene skeleton.
The Minute virus of mice genome has been shown to contain multiple copies of two distinct binding sites for NS1 [69].
Subsequent studies confirmed the presence of two distinct binding sites.
These data, as previously observed Nomura et al. [ 32], suggest the presence of two distinct binding regions of Lys49-PLA2s on membranes: the "active site/hydrophobic channel" and the "C-terminal/myotoxic site".
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