Sentence examples for binding of trophic ligands from inspiring English sources

We have previously described a set of receptors that induces apoptosis following ligand withdrawal, but inhibits apoptosis following the binding of trophic ligands [2] [5].

In the case of APP signaling, binding of a trophic ligand such as netrin-1 increases the production of sAPPα [ 18], which inhibits BACE cleavage [ 19], with the complementary fragment, αCTF, inhibiting γ-secretase cleavage [ 14]; thus cleavage at the α-site produces fragments that inhibit cleavage at the β-site and γ-site rather than feeding back to reduce α-site cleavage.

The dependence receptors listed in Table 1 have all been shown to induce programmed cell death when expressed in the absence of their respective trophic ligands, but not when bound by these same trophic ligands.

It has been demonstrated that the binding of different ligands to ERalpha results in the formation of unique ERalpha-ligand conformations.

The Bet v1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands.

Davies, D. R. et al. Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.

In negative cooperativity, the binding of one ligand makes it harder for a second ligand to bind.

RAR and RXR are intracellular receptors that after binding of ligand function as transcription factors.

The findings show how the binding of a given ligand to its site leads to conformational and functional changes throughout the GABAA receptor, including changes to the binding sites of other ligands.

Subsequent binding of coregulators requires ligand binding.

A measure of the total number of receptors, determined by the binding of agonist or antagonist ligands.