Sentence examples for binding of this region from inspiring English sources

It is tempting to speculate that the binding of this region to CRM1 destabilizes the inward conformation of the HEAT-9 loop, allowing for the latter to be subsequently stabilized in its outward conformation by the RBD.

Further studies are needed to clarify actual roles in RNA binding of this region as well as Gly-rich regions containing several Arg-Gly-Gly motifs in RNA binding, which have been previously implicated in RNA binding of various hnRNP family proteins [12] [14].

The PBR, which activates ING1 and ING2 by binding stress-induced phospholipids, overlaps with the UBD, resulting in competition between ubiquitin and phospholipids for binding of this region.

Specific binding of this region will direct inhibit APP α-secretase activity and reduce APP endocytosis, thereby enhancing cell surface β-CTF accumulation.

Coupled with CHIP analysis showing induced binding of PXR to the UGT1A1 gene following DEX treatment (Fig. 4C) along with previous experiments demonstrating that PXR binding to this region of the UGT1A1 gene stimulates transactivation of the promoter, 3 these findings confirm that induction of UGT1A1 is closely linked to activation of PXR during pregnancy.

The activation mechanism of AC1 is distinct from that of AC8; mutagenesis studies identified a key residue within the C1b domain responsible for Ca2+ regulation of AC1, although the point mutation of this residue did not prevent CaM from binding to this region of AC1.

These results, without undermining the strength of BCL11A as a silencer of the γ globin gene, suggest that the LCR background, by governing the state of BCL11A binding to this region, plays a more significant role in determining the thalassemia phenotype than the level of BCL11A protein expression, that might be influenced by single nucleotide polymorphisms in intronic regions of the BCL11A gene.

We identified a region of the elastin protein that had more immunogenic properties; the different level of IgG binding to this region among the responders, which were classified as such if their OD was above the threshold set at the highest background, was of (9,9) and no responders (19,12), for control and EO-COPD respectively.

Additional research will however be needed to address this possibility, as well as binding experiments to confirm ATFB1 binding to this region of the promoter.

This suggests a model in which the Crumbs complex excludes Baz from the PAR-6/aPKC complex by competing for binding to this region of PAR-6.

It is noteworthy that, as most of the genes in the Hox-D cluster were not upregulated by Nup98-HoxA9, the significance of its binding to this region remains unknown.