Sentence examples for binding of this radioligand from inspiring English sources
[11C]MK-8278 showed more favorable kinetics than [11C]GSK189254 [13], although it still remains to be established whether the specific binding of this radioligand reaches an equilibrium state within the PET image acquisition time.
Although direct measurements from brain are not definitive, we suspect that 11C- R -PK11195 is actually sensitive to genotype in brain under in vivo conditions, similar to the pattern observed in peripheral organs, but the low amount of specific binding of this radioligand requires much larger samples sizes to confirm a statistically significant effect.
Previously, tissue binding of this radioligand was described by the retention parameter calculated from the ratio of the 80 min value divided by the maximal value of the impulse response function.
The saturation binding analysis of this radioligand was consistent with a single population of high affinity CCK receptors (pKD = 10.24).
However, the brain uptake and binding of this PET radioligand are influenced by anesthetic drugs, which are typically needed in preclinical imaging studies and clinical imaging studies involving patient populations that do not tolerate relatively longer scan times.
A basic assumption associated with use of the mediastinum as a reference for H/M and WO calculations is that the counts in this region represent nonspecific binding of the radioligand.
This was interpreted to indicate that obese rats showed decreased DA release and, thus, reduced competition for [C]raclopride to bind to D2R, resulting in increased striatal binding of the radioligand.
The tumor uptake could significantly be decreased by co-injection of unlabeled exendin-4, suggesting specific binding of the radioligand to GLP-1 receptors.
However, the present study found that 11C-LY2428703 cannot image or quantify mGluR1s in monkey or human brain because of very low brain uptake, largely caused by high binding of the radioligand to plasma proteins.
Calculation of the Ki values at A1R, A2AR, A2BR and A3R was approximated using the Cheng-Prusoff equation: Ki = IC50/[1 + (C/KD ], where IC50 is the concentration of compound that displaces the binding of the radioligand by 50%, C is the concentration of radioligand, and KD is the dissociation constant of each radioligand.
