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SPR analysis demonstrated that the binding of this peptide to both Stxs was strong: Kd = 6.6 × 10−6 to Stx-1 and 6.8 × 10−6 to Stx-2.
Interestingly, this peptide contains a potential FxxR/KxR/K PP1-docking motif suggesting that binding of this peptide to PP1c may be involved in the apoptotic process.
The binding of this peptide to the PTP σ receptor has been noted to result in a significant increase in axonal growth after injury [ 112].
This inhibition of P111-136 could be link to a direct or indirect binding of this peptide to the different HARP interacting proteins (ALK, RPTPβ/ζ, nucleolin).
This inhibition could be linked to a direct or indirect binding of this peptide to the HARP receptors (ALK, RPTPβ/ζ, nucleolin).
Moreover, understanding the mechanism of binding of this peptide to these receptors could pave the way for the rational design of drugs that target very specific groups of tyrosine kinase receptors.
Similar(46)
Thus, by introducing only one sDMA and at a defined position (amino acid 112) in SmD3, the sensitivity of binding to this peptide (AARG sDMA GRGMGRGNIF; SMP) was remarkably increased without loss in specificity.
A titration of FHTA against protein preincubated with 5 m m fragment showed no binding of the peptide; this suggests competition between the two ligands.
The binding affinity of this peptide was calculated as −11.59 kcal/mol.
The binding affinity of this peptide was calculated as −9.52 kcal/mol and the Ki value was 105.71 nanomolar.
The binding affinity of this peptide was calculated as −12.96 kcal/mol; the Ki value was 315.78 picomolar.
More suggestions(15)
binding of this antibody
binding of this isoform
binding of this inhibitor
binding of this mutant
binding of this residue
binding of this radiotracer
binding of this drug
binding of this vinculin
binding of this element
binding of this factor
binding of this enzyme
binding of this sequence
binding of this book
binding of this substrate
binding of this complex
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