Sentence examples for binding of this compound from inspiring English sources
An in silico model for the binding of this compound to hTK1 was developed.
[111In]JMV4168 uptake could be blocked almost completely with an excess of cold labeled peptide, illustrating the specific binding of this compound.
Circular Dichroism (CD) measurements confirmed the sequence-dependent binding of this compound and suggest insertion in the minor groove as shown by a strong induced CD (ICD) signal and further supported by molecular modeling.
Furthermore, the binding of this compound and its displacement from the active site can be followed by fluorescence measurements, which allows a rapid evaluation of the CYP 3A4 affinity of any new drug candidate.
A concentration of 50 µM DBB was required to detect binding of this compound to intracellular components, as observed by confocal fluorescence microscopy (results not shown).
The nuclear import defect at low concentrations of PF74 may be caused by binding of this compound to a reactive groove on the viral capsid, leading to competitive inhibition of capsid interaction with the host proteins Nup153 and CPSF6 (Matreyek et al., 2013; Price et al., 2014).
Here, we exhaustively assess the atomistic binding interactions of this compound with both CCR5 and CXCR4, and we find that binding is driven by π-stacking interactions between aromatic rings on the ligand and receptor residues, as well as electrostatic interactions involving the protonated piperidine nitrogen.
The in vitro studies show a high binding affinity of this compound to melanoma cells.
The binding mode of this compound in tubulin was predicted using the molecular docking simulation.
The binding ability of this compound and glucose to MIPs is speculated to be based on the same interaction due to their similar chemical structure.
Furthermore, compound 3-2 waselecteded as a representative molecule, and the probable binding mode of this compound and the surrounding residues in the active site of 3HNR was elucidated by using molecular dock.
