Sentence examples for binding of this class from inspiring English sources

The results suggest that van der Waals energies mostly drive the binding of this class of inhibitors to HIV-1 protease.

Altered binding of this class of proteins to ARE in the 3' UTR of mRNA ultimately leads to increased stability of a specific mRNA and expression of its encoded protein [31].

Thus, binding of this class of ligand must involve a significant trade-off between entropy costs for immobilization of the ligand and additional favorable contacts in a much more extended binding site.

Previously it has been shown that methionine 82 plays an important role as gatekeeper residue in the docking mode of isoxazoles to the ATP binding pocket since mutation of methionine 82 to phenylalanine blocks binding of this class of CK1δ specific inhibitors (Peifer et al. 2009) while still binding ATP.

Disruption of the planar indolocarbazole ring system through the sp hybridization of the two carbons at the base of the pyrrole ring in the indolotryptoline structure is likely to lead to an altered mode of binding of this class of tryptophan dimers.

Hydrophobic contribution through membrane insertion will likely be an important component of membrane binding for this class, similar to FENS-FYVE [ 22], which localizes to endosomal membrane [ 66] even though it has a weaker positive potential than other known FYVE domains [ 22].

Because the binding properties of this class of biosensors are affected by how well the biosensor switches between binding and non-binding conformations, we investigated the effects of varying conformational stability on the ability of biosensors to detect the oncologically-relevant Myc/Max TF dimer complex.

Using truncated versions of the cytokinin receptor CRE1/AHK4 in a binding assay, we have experimentally defined the CHASE domain as the ligand binding domain of this class of receptor.

In this work, we have docked this series of peptidomimetics into the TR binding site, using the FlexX algorithm as implemented in the Sybyl program, in order to access the binding mode of this class of compounds in the target enzyme.

Antibacterial activities and DNA binding affinity of this class of cadmium complexes have attracted considerable interest.

Understanding of the binding mode of this class of compound using ADAM-TS1 as a structural surrogate has led to the discovery of potent and very selective inhibitors with favourable DMPK properties.