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The binding of the virus with host cell receptor components is critical for infection.
The main mechanism of anti-HIV-1 activity associated with these compounds involves electrostatic interactions with HIV-1 glycoprotein 120 that ultimately prevent binding of the virus to target cells.
We then determined that virus removal by this chromatography resin is strongly disrupted by the presence of high salt concentrations or by the absence of the positively charged Q ligand, indicating that binding of the virus to the resin is primarily due to electrostatic forces, and that any non-electrostatic interactions which may be present are not sufficient to provide virus removal.
There are six basic, overlapping stages in the life cycle of viruses in living cells: Attachment is the binding of the virus to specific molecules on the surface of the cell.
HA is a lectin that mediates binding of the virus to target cells and entry of the viral genome into the target cell, while NA is involved in the release of progeny virus from infected cells, by cleaving sugars that bind the mature viral particles.
Host cell entry of HPV is initiated by binding of the virus particle to specifically modified heparan sulfate proteoglycans (HSPGs) [3], [4].
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The high concentration of Ni++ ions in the buffer was chosen for a tight electrostatic binding of the viruses only.
In the present study biophysical methods such as SPR will be used to examine the effect of micelle formation of palmitoyl peptides with binding to the receptor binding site of the virus surface protein HA.
This amino acid is located in the antigenic site Ca2 in the immediate vicinity of the receptor binding pocket and it may influence binding preferences of the virus [9], [10].
The WSSV binding proteins isolated from viral particles in the haemolymph of shrimp infected with WSSV, have been shown to inhibit the binding of this virus to haemolymph cells and improve survival of shrimp [ 22].
Even minor changes in the hemagglutinin molecule may affect receptor binding specificity of the virus, and a single point mutation in the neuraminidase may render the virus resistant to oseltamivir.
More suggestions(16)
binding of the known
binding of the cofactor
binding of the antibody
binding of the sera
binding of the myosin
binding of the peptide
binding of the fusion
binding of the radiolabel
binding of the radioligand
binding of the heterodimer
binding of the target
binding of the ligand
binding of the karma
binding of the initiator
binding of the nation
binding of the protein
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